Lumbar Disc Arthroplasty

Primary Operative Indications

  • Discogenic low back pain with ALL of the following:
  • Pain arising from 1 or 2-level disc disruption involving L3-4, L4-5, and/or L5-S1 segments
  • Presence of symptoms 6 months or greater
  • Failed nonoperative management, including but not limited to:
    • >6 weeks of PT
    • injections, pain medications…etc.
  • Primary complaint of axial back pain, with a possible secondary complaint of lower extremity pain
  • Age 18-60

Contraindications

  • Presence of symptomatic degenerative disc disease at more than 2 levels
  • Facet joint arthropathy, with signs that primary source of pain is facet mediated
    • Possible to perform in patients with asymptomatic facets with Pathria Grade 1-3, not Grade 4
  • Instability with spondylolisthesis greater than Grade 1
  • Presence of any pars defect
  • Leg pain predominance, chronic radiculopathy (unremitting pain with predominance of leg pain greater than back pain, extending over at least one year)
  • Osteopenia, DEXA T-score < or equal to -1.0
    • Possible for patients >~1.5 T-Score on Dexa scan
      • Hounsfield units as measured on CT, not as reliable
  • Poorly managed psychiatric disorder
  • Age >60 years or <18 years
  • Presence of infection or tumor
  • Moderate to severe scoliosis or major deformity
  • More than 40-50% loss of endplates surface area due to cysts or other severe endplate abnormality
  • Facet ankylosis
  • Metal allergy or history of implant rejection
  • AP length of vertebral body smaller than implant size
    • <27mm for the Prodisc-L
  • High risk anterior approach
    • Vascular calcification
    • Previous vascular surgery in area of anterior spine
    • Retroperitoneal radiation
    • Abarrant vascular anatomy
    • Obesity (varied based on surgeon experience)

Relative Contraindications (Debated)

  • 3-level disease
  • Age >60 years possible with adequate bone quality without circumferential stenosis (Bertagnoli, 2006)
  • Osteopenia, DEXA T-score < or equal to -1.0
    • Possible for patients >~1.5 T-Score on Dexa scan
  • Instability with spondylolisthesis greater than Grade 1
    • (Some surgeons would say that you should avoid lumbar ADR with any amount of anterolisthesis)
    • Retrolisthesis acceptable if Grade 1 or less
  • Facet joint arthropathy
    • Possible to perform in patients with relatively asymptomatic facets with Pathria Grade 1-3, not Grade 4
  • Prior laminectomy at lumbar ADR level
  • Scoliosis, >15degrees
    • Some surgeons tolerate scoliosis if no lateral listhesis at target disc, not at apex and <~15 degrees.
  • High sacral slope >~80 degrees, though some research says higher SS is not a contraindication (Arunakul, 2017)

Important Outcome Considerations

Workup

  • Xray L-spine
    • AP view, used to match intraop AP rotation
    • Lateral, measure alignment for target sagittal balance
    • Flexion/Extension view, identify instability
    • EOS, consider full spine alignment
  • CT L-spine
    • Look for sclerotic endplates, may require sharper enplate cutter due to difficulty cutting through endplates
    • Some consider Spec-CT as an option to help identify painful level as it may correlate with active disc inflammation (not yet literature based)
  • MRI without contrast, L-Spine
    • Review disc degeneration
    • Review for stenosis or disc hernations
    • Review foraminal stenosis
    • Review health of the facets

Implant Options

  • Current options
  • Historical options
    • Functional three-component
    • Functional two-component
      • Maverick by Medtronic
      • Flexicore by Stryker
      • XL TDR by NuVasive
    • Functional one-component
      • Freedom by AxioMed
      • M6-L by Spinal Kinetics
      • Cadisc-L by Ranier
      • LP-ESP by FH Orthopedics
      • Physio-L by K2m

Evidence

References

  1. NASS Clinical Guidelines
  2. Jacobs W, Van der Gaag NA, Tuschel A, et al. Total disc replacement for chronic back pain in the presence of disc degeneration: a Cochrane review. Spine. 2013 Jan 1;38(1):24-36. doi: 10.1097/BRS.0b013e3182741b21.
  3. Büttner-Janz K, Guyer RD, Ohnmeiss DD. Indications for lumbar total disc replacement: selecting the right patient with the right indication for the right total disc. Int J Spine Surg. 2014 Dec 1;8:12. doi: 10.14444/1012. PMID: 25694946; PMCID: PMC4325514.
  4. Yue JJ. Long-term prospective randomized outcomes following lumbar total disc replacement: a single site experience with 6 years follow-up; Paper presented at: ISASS16. April 6, 2016; Las Vegas, NV.
  5. Meir AR, Freeman BJ, Fraser RD, Fowler SM. Ten-year survival and clinical outcome of the AcroFlex lumbar disc replacement for the treatment of symptomatic disc degeneration. Spine J. 2013;13(1):13-21.
  6. Lu SB, Hai Y, Kong C, et al. An 11-year minimum follow-up of the Charite III lumbar disc replacement for the treatment of symp- tomatic degenerative disc disease. Eur Spine J. 2015;24(9):2056-2064.
  7. Sköld C, Tropp H, Berg S. Five-year follow-up of total disc replacement compared to fusion: a randomized controlled trial. Eur Spine J. 2013;22(10):2288-95. FILE-ALT
  8. Ma L, Yang S, Wang H, Zhang D, Ding W. Two- and five-year follow-up of lumbar total disc replacement compared to fusion: a meta-analysis. Intl J Clin Exper Med. 2016;9(2):485-494
  9. Radcliff K, Zigler J, Braxton E, et al. Final Long-Term Reporting from a Randomized Controlled IDE Trial for Lumbar Artificial Discs in Single-Level Degenerative Disc Disease: 7-year Results. Int J Spine Surg.2021;15(4):612-32. FILE-ALT
  10. Zigler J, Gornet MF, Ferko N, Cameron C, Schranck FW, Patel L. Comparison of lumbar total disc replacement with surgical spinal fusion for the treatment of single-level degenerative disc disease: a meta-analysis of 5-year outcomes from randomized con- trolled trials. Global Spine J. 2017;8(4):413-423. FILE-ALT
  11. Harrop JS, Youssef JA, Maltenfort M, et al. Lumbar adjacent segment degeneration and disease after arthrodesis and total disc arthroplasty. Spine. 2008;33(15):1701-7.
  12. GragnanielloC,SeexKA,EisermannLG,ClaydonMH,MalhamGM.EarlypostoperativedislocationoftheanteriorMavericklumbar disc prosthesis: report of 2 cases. J Neurosurg Spine. 2013;19(2):191-6.
  13. Eskander MS, Onyedika II, Eskander JP, Connolly PJ, Eck JC, Lapinsky A. Revision strategy for posterior extrusion of the CHARITÉ polyethylene core. Spine. 2010;35(24):E1430-4.
  14. VanooijA,OnerFC,VerboutAJ.Complicationsofartificialdiscreplacement:areportof27patientswiththeSBCharitédisc.JSpinal Disord Tech. 2003;16(4):369-83.
  15. Kurtz SM, Van ooij A, Ross R, et al. Polyethylene wear and rim fracture in total disc arthroplasty. Spine J.2007;7(1):12-21.
  16. MarnayTP.106.Seven-to21-yearclinicaloutcomesof1,187patientstreatedwithone-andtwo-levellumbartotaldiscarthroplasty. Spine J. 2021;21(9):S52.
  17. Rasouli A, Cuellar JM, Kanim L, Delamarter R. Multiple-Level Lumbar Total Disk Replacement: A Prospective Clinical and Radiographic Analysis of Motion Preservation at 24-72 Months. Clin Spine Surg. 2019;32(1):38-42.
  18. RehmatullahN,MorganC,GoruP,ShacklefordI.Singleandmultiplelevellumbardiscarthroplastyfordegenerativelumbardiscdisease: Outcome data at 24 months. Spine J. 2017;17(3):S8.
  19. Scott-YoungM,McEnteeL,ZottiM,etal.Patient ReportedOutcomeMeasuresAfterMultilevelLumbarTotalDiscArthroplastyfor the Treatment of Multilevel Degenerative Disc Disease. Spine. 2020 Jan 1;45(1):18-25.
  20. Hoff EK, Strube P, Pumberger M, Zahn RK, Putzier M. ALIF and total disc replacement versus 2-level circumferential fusion with TLIF: a prospective, randomized, clinical and radiological trial. Eur Spine J. 2016 May;25(5):1558-1566. doi: 10.1007/s00586-015- 3852-y. Epub 2015 Mar 7.