Basics

Enneking Staging System 

Benign Lesions 

  1. Latent lesion 
    1. (HOOG) Hemangioma, Osteoid Osteoma, Osteochondroma, Granuloma Eosinophilic 
    2. Observation 
    3. Mx: intralesional excision +/- adjuvants (liquid nitrogen, phenol, PMMA) 
  2. Active lesion 
    1. (HOOOGA) Osteoid osteoma, osteochrondroma, hemangioma, eosinophilic granuloma, ABC 
    2. Mx: en bloc resection vs intralesional excision +/- adjuvants (liquid nitrogen, phenol, PMMA) 
  3. Aggressive lesion 
    1. GCT, osteoblastoma 
    2. Mc: wide excision (cuff of normal tissue) 

Malignant Lesions 

  1. Low grade 
  2. High grade 
  3. Metastatic 
  1. Intracompartmental  
  2. Extracompartmental 

DDx Categories 

Age, Location, Size  

Age 

Young 10-30 

Middle 30-50 

Older 50+ 

Location 

Bone (Vertebrae) 

  • Anterior (more malignant) 
    • Myeloma 
    • Ewings 
    • Osteosarcoma 
  • Posterior (more benign) 
    • OOGA 

Non-Bone (Spinal Cord) 

  • Intradural Extramedullary 
    • Schwannoma 
    • Meningioma 
  • Intradural Intramedullary 
    • Ependymoma 
    • Astrocytoma 
      • Usually benign 
    • Intramedullary mets -> <3mo life expectancy 
  • Extradural 
    • Metastasis 
      • Extramedullary 
        • Drop mets via CSF 
      • Intramedullary 
    • Lymphoma 
      • T2 hyperintense with marked homogenous contrast 
      • Treatment: methotrexate 

Scenarios and Responses 

  • No current Ca Hx (includes people with no current Ca but +ve remote Ca Hx), Painful spine lesion in <40 – refer to ortho onc; likely biopsy  
  • No current Ca Hx (includes people with no current Ca but +ve remote Ca Hx), Painful spine lesion in >40 – do mets staging workup because probably mets, but need to confirm 
  • Current Ca Hx no fracture, Mirel Score <9 staging workup, bisphosphonates or denosumab  to reduce risk of fracture 
  • Current Ca with Impending Fracture – curretage with cement, fix hip to femur, post op rads 
  • Path Fracture – Staging workup – core needle 

Mirel Score – fix if >9 

  • Location 
    • Upper 
    • Lower 
    • Pertroch 
  • Pain 
    • Non 
    • Moderate 
    • Functional 
  • Lesion 
    • Blastic 
    • Mixed 
    • Lytic 
  • Size 
    • 1/3 
    • 2/3 
    • 3/3